Importantly, small molecule inhibition of CDK2 does not induce a clean arrest in the G1phase of the cell cycle, but instead it leads to a G2/M block or an intra-S phase arrest, which is the outcome of treatment with various toxic chemotherapeutic agents that lead to cell death (45,57)
Importantly, small molecule inhibition of CDK2 does not induce a clean arrest in the G1phase of the cell cycle, but instead it leads to a… Read More »Importantly, small molecule inhibition of CDK2 does not induce a clean arrest in the G1phase of the cell cycle, but instead it leads to a G2/M block or an intra-S phase arrest, which is the outcome of treatment with various toxic chemotherapeutic agents that lead to cell death (45,57)