They could be formed either with the cyclization of linear octa-[40], [41],[32],and[42]22-(Hydroxymethyl)-AQH HOCH2 HHHHHH [43] and??[44]32-Methoxy-AQH MeO HHHHHH [42]42-Hydroxy-AQH OH HHHHHH [42]51-Methoxy-AQOH H HHHHHH [45, 46]61-Hydroxy-2-methyl AQOH Me personally HHHHHH [42][46][39][39][39], [39], andRubia yunnanensis[43]71-Hydroxy-2-(hydroxymethyl)-AQOH HOCH2 HHHHHH [32]82-(Ethoxycarbonyl)-1-hydroxy-AQOH EtOOC HHHHHH [39]91-Methoxy-2-methyl-AQMeO Me personally HHHHHH [39],[39], and[47]11Alizarin 2-methyl ether[42][39],[32], and [47]12Alizarin 1-methyl ether[42]13Alizarin 1,2-dimethyldiether[42]14Rubiadin (1,3-dihydroxy-2-[40][42][32], and[39],Rubia yunnanensis[43]15Lucidin (1,3-dihydroxy-2-[32][42], and[33]16Nordamnacanthal (1,3-dihydroxy-2-formyl-AQ)OHCHOOHHHHHH [32] and Rubia iberica[33] 17Munjistin (1,3-dihydroxy-2-carboxy-AQ)OHHOOCOHHHHHH [42]181,3-Dihydroxy-2-(methoxycarbonyl)-AQOHMeOOCOHHHHHH [32]192-(Ethoxymethyl)-1,3-dihydroxy-AQOHEtOCH2 OHHHHHH [32]201,3-Dihydroxy-2-(methoxymethyl)-AQOHMeOCH2 OHHHHHH [32] 21Lucidin dimethyl etherMeOHHOCH2 MeOHHHHH [39]22Munjistin dimethyl ether (2-carboxy-[32]232-BenzylxanthopurpurinOHPhCH2 OHHHHHH [32]24Anthragallol 3-methyl etherOHOHMeOHHHHH [42]25Anthragallol 2,3-dimethyl etherOHMeOMeOHHHHH [32] 262-Carboxy-1-hydroxy-3-methoxy-AQOHHOOCMeOHHHHH [48]273-Hydroxy-1-methoxy-2-(methoxymethyl)-AQMeOMeOCH2 OHHHHHH [49]28Anthragallol (1,2,3-trihydroxy-AQ)OHOHOHHHHHH [32]29Purpurin (1,2,4-trihydroxy AQ)OHOHHOHHHHH [32, 42][32][33][33], andRubia tetragona[32]30Quinizarin (1,4-dihydroxy-AQ)OHHHOHHHHH [32] andRubia tinctorum[32]311,4-Dihydroxy-2-(hydroxymethyl)-AQOHHOCH2 HOHHHHH [32] andRubia yunnanensis[32]322-(Ethoxycarbonyl)-1,4-dihydroxy-AQOHEtOOCHOHHHHH [32]33Christophine (2-(ethoxymethyl)-[32]341,4-Dihydroxy-2-methyl-AQOHMeHOHHHHH [32] and [32]35Xanthopurpurin (1,3-dihydroxy-AQ)OHHOHHHHHH [32][32][39][43],36Xanthopurpurin 3-methyl ether[32]37Xanthopurpurin dimethyl ether (1,3-dimethoxy-AQ)MeOHMeOHHHHH [32] 381-Hydroxy-3-(methoxycarbonyl)-AQOHHMeOOCHHHHH [32], [39], and [39]39Pseudopurpurin (3-(carboxy)-1,2,4-trihydroxy-AQ)OHOHHOOCOHHHHH [32][32][32]401,4-Dihydroxy-2-methyl-5-methoxy-AQOHMeHOHMeOHHH [50]411,4-Dihydroxy-2-methyl-8-methoxy-AQOHMeHOHHHHMeO [50]421,4-Dihydroxy-6-methyl-AQOHHHOHHMeHH [51]431,5-Dihydroxy-2-methyl-AQOHMeHHOHHHH [51]44Physcion (1,8-dihydroxy-3-methoxy-6-methyl-AQ)OHHMeHHMeHOH [50] and[52]452-Methyl-1,3,6-trihydroxy-AQOHMeOHHHOHHH [32][32][43], [32], and[32]461,4-Dihydroxy-7-methyl-AQOHHHOHHHMeH [50]474,5-Dihydroxy-2-methoxy-7-methyl-AQHMeHOHOHHMeOH [50]482,7-Dihydroxy-4-methoxy-3-methyl-AQHOHMeMeOHHOHH [32]492-Hydroxy-7-methyl-AQHMeHHHHOHH [32]502-Carboxy-4-hydroxy-AQHHOOCHOHHHHH [32] 51 3-([32]523-(6-O-Acetyl-[32] 533-[(2-O-6-Deoxy-[32], [32][39],[43] 543-[(3-O-Acetyl-2-O-6-deoxy-[32]553-[(6-O-Acetyl-2-O-6-deoxy-[32][39],[43][32]563-[(3,6-O-Diacetyl-2-O-6-deoxy-[32]573-[(4,6-O-Diacetyl-2-O-6-deoxy-[32]583-[(4-O-Acetyl-2-O-6-deoxy-[32]593-[(6-O-Acetyl-2-O-[32]60Ruberythric acidity (1-hydroxy-2-[(6-O-[32][32], and?[45]61Lucidin primeveroside (1-hydroxy-2-(hydroxymethyl)-3-[(6-O-[32][32][45], and [32] 632-[(6-O-[32] and[32]643-[(2-O-6-Deoxy-[32]653-([32]663-([32] 672-([32]683-([32]69Emodin (1,3,8-trihydroxy-6-methyl-AQ)OHHMeHHOHHOH [28, 52]70Cascarin (emodin 6-O-rhamnoside)OHHMeHHRhaOHOH [28]73Aloe-emodin (1,8-dihydroxy 3-hydroxy methyl anthraquinone)OHHCH2OHHHHHOH [53], [53], andRheum rhaponticum[53]74Chrysophanol (1,8-dihydroxy-3-methyl-AQ)OHHMeHHMeOHOH Fallopia japonicaF

They could be formed either with the cyclization of linear octa-[40], [41],[32],and[42]22-(Hydroxymethyl)-AQH HOCH2 HHHHHH [43] and??[44]32-Methoxy-AQH MeO HHHHHH [42]42-Hydroxy-AQH OH HHHHHH [42]51-Methoxy-AQOH H HHHHHH [45,… Read More »They could be formed either with the cyclization of linear octa-[40], [41],[32],and[42]22-(Hydroxymethyl)-AQH HOCH2 HHHHHH [43] and??[44]32-Methoxy-AQH MeO HHHHHH [42]42-Hydroxy-AQH OH HHHHHH [42]51-Methoxy-AQOH H HHHHHH [45, 46]61-Hydroxy-2-methyl AQOH Me personally HHHHHH [42][46][39][39][39], [39], andRubia yunnanensis[43]71-Hydroxy-2-(hydroxymethyl)-AQOH HOCH2 HHHHHH [32]82-(Ethoxycarbonyl)-1-hydroxy-AQOH EtOOC HHHHHH [39]91-Methoxy-2-methyl-AQMeO Me personally HHHHHH [39],[39], and[47]11Alizarin 2-methyl ether[42][39],[32], and [47]12Alizarin 1-methyl ether[42]13Alizarin 1,2-dimethyldiether[42]14Rubiadin (1,3-dihydroxy-2-[40][42][32], and[39],Rubia yunnanensis[43]15Lucidin (1,3-dihydroxy-2-[32][42], and[33]16Nordamnacanthal (1,3-dihydroxy-2-formyl-AQ)OHCHOOHHHHHH [32] and Rubia iberica[33] 17Munjistin (1,3-dihydroxy-2-carboxy-AQ)OHHOOCOHHHHHH [42]181,3-Dihydroxy-2-(methoxycarbonyl)-AQOHMeOOCOHHHHHH [32]192-(Ethoxymethyl)-1,3-dihydroxy-AQOHEtOCH2 OHHHHHH [32]201,3-Dihydroxy-2-(methoxymethyl)-AQOHMeOCH2 OHHHHHH [32] 21Lucidin dimethyl etherMeOHHOCH2 MeOHHHHH [39]22Munjistin dimethyl ether (2-carboxy-[32]232-BenzylxanthopurpurinOHPhCH2 OHHHHHH [32]24Anthragallol 3-methyl etherOHOHMeOHHHHH [42]25Anthragallol 2,3-dimethyl etherOHMeOMeOHHHHH [32] 262-Carboxy-1-hydroxy-3-methoxy-AQOHHOOCMeOHHHHH [48]273-Hydroxy-1-methoxy-2-(methoxymethyl)-AQMeOMeOCH2 OHHHHHH [49]28Anthragallol (1,2,3-trihydroxy-AQ)OHOHOHHHHHH [32]29Purpurin (1,2,4-trihydroxy AQ)OHOHHOHHHHH [32, 42][32][33][33], andRubia tetragona[32]30Quinizarin (1,4-dihydroxy-AQ)OHHHOHHHHH [32] andRubia tinctorum[32]311,4-Dihydroxy-2-(hydroxymethyl)-AQOHHOCH2 HOHHHHH [32] andRubia yunnanensis[32]322-(Ethoxycarbonyl)-1,4-dihydroxy-AQOHEtOOCHOHHHHH [32]33Christophine (2-(ethoxymethyl)-[32]341,4-Dihydroxy-2-methyl-AQOHMeHOHHHHH [32] and [32]35Xanthopurpurin (1,3-dihydroxy-AQ)OHHOHHHHHH [32][32][39][43],36Xanthopurpurin 3-methyl ether[32]37Xanthopurpurin dimethyl ether (1,3-dimethoxy-AQ)MeOHMeOHHHHH [32] 381-Hydroxy-3-(methoxycarbonyl)-AQOHHMeOOCHHHHH [32], [39], and [39]39Pseudopurpurin (3-(carboxy)-1,2,4-trihydroxy-AQ)OHOHHOOCOHHHHH [32][32][32]401,4-Dihydroxy-2-methyl-5-methoxy-AQOHMeHOHMeOHHH [50]411,4-Dihydroxy-2-methyl-8-methoxy-AQOHMeHOHHHHMeO [50]421,4-Dihydroxy-6-methyl-AQOHHHOHHMeHH [51]431,5-Dihydroxy-2-methyl-AQOHMeHHOHHHH [51]44Physcion (1,8-dihydroxy-3-methoxy-6-methyl-AQ)OHHMeHHMeHOH [50] and[52]452-Methyl-1,3,6-trihydroxy-AQOHMeOHHHOHHH [32][32][43], [32], and[32]461,4-Dihydroxy-7-methyl-AQOHHHOHHHMeH [50]474,5-Dihydroxy-2-methoxy-7-methyl-AQHMeHOHOHHMeOH [50]482,7-Dihydroxy-4-methoxy-3-methyl-AQHOHMeMeOHHOHH [32]492-Hydroxy-7-methyl-AQHMeHHHHOHH [32]502-Carboxy-4-hydroxy-AQHHOOCHOHHHHH [32] 51 3-([32]523-(6-O-Acetyl-[32] 533-[(2-O-6-Deoxy-[32], [32][39],[43] 543-[(3-O-Acetyl-2-O-6-deoxy-[32]553-[(6-O-Acetyl-2-O-6-deoxy-[32][39],[43][32]563-[(3,6-O-Diacetyl-2-O-6-deoxy-[32]573-[(4,6-O-Diacetyl-2-O-6-deoxy-[32]583-[(4-O-Acetyl-2-O-6-deoxy-[32]593-[(6-O-Acetyl-2-O-[32]60Ruberythric acidity (1-hydroxy-2-[(6-O-[32][32], and?[45]61Lucidin primeveroside (1-hydroxy-2-(hydroxymethyl)-3-[(6-O-[32][32][45], and [32] 632-[(6-O-[32] and[32]643-[(2-O-6-Deoxy-[32]653-([32]663-([32] 672-([32]683-([32]69Emodin (1,3,8-trihydroxy-6-methyl-AQ)OHHMeHHOHHOH [28, 52]70Cascarin (emodin 6-O-rhamnoside)OHHMeHHRhaOHOH [28]73Aloe-emodin (1,8-dihydroxy 3-hydroxy methyl anthraquinone)OHHCH2OHHHHHOH [53], [53], andRheum rhaponticum[53]74Chrysophanol (1,8-dihydroxy-3-methyl-AQ)OHHMeHHMeOHOH Fallopia japonicaF

A

A. signaling component (set to 1/10 nominal value) is not able to reduce IKK activation.(EPS) pcbi.1003471.s004.eps (576K) GUID:?13CF5024-D8CA-49D3-B183-AA5FFFF347D9 Figure S5: Simulations of additional plausible scenarios… Read More »A